|
Tumor Cell Invasion
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Women with the rs2289937 C genotype (CC+CT) of rs4570 and rs4579555 genotypes and haplotype 1 (TTTCAGGCGC) were significantly associated with CC risk, while women with low frequencies of haplotype 6 (TTTTAGGCGC) also increased the risk of CC.Rad21-specific shRNA decreased cancerous cell proliferation, migration, and invasion and increased the proportion of cells in G2/M phase as well as sensitivity to radiation.
|
29797792 |
2018 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
We report that RAD21, a subunit of the cohesin complex, is expressed in epithelial breast cancer cells, whereas its expression is decreased in mesenchymal cancer.
|
27466323 |
2016 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We report that RAD21, a subunit of the cohesin complex, is expressed in epithelial breast cancer cells, whereas its expression is decreased in mesenchymal cancer.
|
27466323 |
2016 |
|
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We performed an immunohistochemical analysis of RAD21 expression in a cohort of 94 familial breast cancers (28 BRCA1, 27 BRCA2, and 39 BRCAX) and correlated these data with genotype and clinicopathologic parameters, including survival.
|
22537934 |
2012 |
|
Familial (FPAH)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We performed an immunohistochemical analysis of RAD21 expression in a cohort of 94 familial breast cancers (28 BRCA1, 27 BRCA2, and 39 BRCAX) and correlated these data with genotype and clinicopathologic parameters, including survival.
|
22537934 |
2012 |
|
Chronic intestinal pseudo-obstruction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We identified a homozygous mutation (p.622, encodes Ala>Thr) in RAD21 in patients from a consanguineous family with CIPO.
|
25575569 |
2015 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that TCEB1, EIF3S3, KIAA0196 and RAD21 are amplified and overexpressed in prostate cancer and they are located in the 8q area.
|
18844214 |
2009 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that TCEB1, EIF3S3, KIAA0196 and RAD21 are amplified and overexpressed in prostate cancer and they are located in the 8q area.
|
18844214 |
2009 |
|
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We found that siRNA-targeted depletion of a cohesin subunit, RAD21, decreased MYC expression in ER-positive (MCF7 and T47D) and ER-negative (MDA-MB-231) breast cancer cell lines.
|
23145106 |
2012 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We found that siRNA-targeted depletion of a cohesin subunit, RAD21, decreased MYC expression in ER-positive (MCF7 and T47D) and ER-negative (MDA-MB-231) breast cancer cell lines.
|
23145106 |
2012 |
|
Malignant neoplasm of breast
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We found that 12 of the polymorphisms are associated with breast or breast and ovarian cancers, most notably rs16888927, rs16888997, and rs16889040, found in introns of RAD21, suggesting that SNPs in other genes in the DSBR pathway in addition to BRCA1 and BRCA2 may affect breast cancer risk.
|
19276285 |
2009 |
|
Breast Carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We found that 12 of the polymorphisms are associated with breast or breast and ovarian cancers, most notably rs16888927, rs16888997, and rs16889040, found in introns of RAD21, suggesting that SNPs in other genes in the DSBR pathway in addition to BRCA1 and BRCA2 may affect breast cancer risk.
|
19276285 |
2009 |
|
Malignant neoplasm of ovary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that 12 of the polymorphisms are associated with breast or breast and ovarian cancers, most notably rs16888927, rs16888997, and rs16889040, found in introns of RAD21, suggesting that SNPs in other genes in the DSBR pathway in addition to BRCA1 and BRCA2 may affect breast cancer risk.
|
19276285 |
2009 |
|
Hypoglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also found that hypoglycemia and heat shock significantly decreased the hHR21(SP) level, indicating that a DNA double-strand break repair gene, hHR21(SP) might be regulated by environmental stresses.
|
11243849 |
2001 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Using an orthotopic tumor model of human OSCC (UM-SCC1) injected in the tongue of BALB/c nude mice, we showed that treatment with 2-DG in vivo significantly inhibited the metastasis of tumor cells to the regional cervical lymph nodes and reduced the expression of ALDH1 and vimentin in both in situ tumors and tumor cell-invaded regional lymph nodes.
|
27926487 |
2017 |
|
Squamous cell carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Two types of squamous cell carcinoma (SCC) occurred in a mandibular (SCC-1) and maxillary gingiva (SCC-2), but their clinical features and progression were quite different from each other.
|
28789700 |
2017 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Two genes from chromosomal region 8q24-RAD21 and KIAA0196-showed increased expression in clinical prostate carcinomas and were also amplified in 30-40% of xenografts and hormone-refractory tumors.
|
14603436 |
2004 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Two genes from chromosomal region 8q24-RAD21 and KIAA0196-showed increased expression in clinical prostate carcinomas and were also amplified in 30-40% of xenografts and hormone-refractory tumors.
|
14603436 |
2004 |
|
Cornelia De Lange Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Two genes (CREBBP and EP300) are known to cause RTS, and five (NIPBL, SMC1A, SMC3, RAD21, and HDAC8) have been associated with CdLS.
|
24352918 |
2014 |
|
Laryngeal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Treatment of human HNSCC cell lines from different sub-sites, such as oral cavity (SCC1), larynx (SCC5), tongue (OSC19) and pharynx (FaDu), with grape seed proanthocyanidins (GSPs) reduced their cell viability and induced cell death in a dose- and time-dependent manner.
|
23050025 |
2012 |
|
Malignant neoplasm of lung
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Transcription factor Dp family member 3 and RAD21 cohesin complex component are important transcription factors in microRNA-21-interfered lung cancer.
|
31506038 |
2019 |
|
Carcinoma of lung
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Transcription factor Dp family member 3 and RAD21 cohesin complex component are important transcription factors in microRNA-21-interfered lung cancer.
|
31506038 |
2019 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transcription factor Dp family member 3 and RAD21 cohesin complex component are important transcription factors in microRNA-21-interfered lung cancer.
|
31506038 |
2019 |
|
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
To determine whether suppression of RAD21 expression influences cellular proliferation, RNA interference technology was used in breast cancer cell lines MCF-7 and T-47D.
|
15767545 |
2005 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
To determine whether suppression of RAD21 expression influences cellular proliferation, RNA interference technology was used in breast cancer cell lines MCF-7 and T-47D.
|
15767545 |
2005 |